Another monster Covid vaccine update, with sections on major turning points you might have missed, "real world evidence", immunosuppressed people, and trials in children and teenagers. At Absolutely Maybe – New Vaccine Hopes, Adverse Reactions, & a Developer Clashing with Regulators: A Month of Highs and Lows.

My April talk at the Virtually Cochrane 2021 meeting is now a blog post – Systematic Evidence and the Covid-19 Stress Test: Pass or Fail? With my thanks to the organizers and participants, who gave me a lot to think about!




First up, something I've been wanting to get around to for a long time – spurred on now by a particularly egregious example of handling criticism badly. At Absolutely Maybe, A Cartoon Guide to Criticism: Scientist Edition.

And soon after, I had to decide how to put this into practice, when I read a critique by Steven Salzberg, of my most recent post in The Atlantic. In this case, my response is a rebuttal.



Seen the narrative that efficacy against hospitalizations & deaths is 100% for all Covid vaccines? They're amazing, but we don't know how high that protection is. Exaggerating vaccine benefits is risky: we can do better than this! My 1st piece at The Atlantic: The Differences Between the Vaccines Matter.

I've got a data dive on hospitalizations & deaths for the 6 vaccines used to support that "100% efficacy" claim, and the data behind The Atlantic op-ed here at this website.

And a second piece at The Atlantic - this time about the serious blood disorders being investigated around the Oxford-AstraZeneca vaccine.

Over at Absolutely Maybe, another vaccine roundup – Community Impact Data, 3 New Covid Vaccines, and Trials in Children: A Month of Dilemmas and Good News.

Plus another thing Covid-19 has brought to our lives: The Pioneering Crossover Trials for Covid Vaccines and What We'll Find Out. Supported by a post at Statistically Funny, returning after a long hiatus: In clinical trials, you can have it both ways.



An interview with me on vaccines by Julia Belluz at Vox: The scientist who's been right about Covid-19 vaccines predicts what's next. In which Julia asks tough questions and excels at getting me to say what I really think! (No one expects an Australian to be diplomatic, right?? Right!)

I think it's the most poorly communicated part of vaccine evidence – adverse events. Here's how not to get caught in a bunch of common traps – like, "adverse events were mostly mild and moderate". Spoiler: severe adverse events never outnumber the others – it doesn't tell you anything. At Absolutely Maybe: A Reader's Guide to Safety & Adverse Events Data From Clinical Trials.

Even when I tried to write a non-Covid vaccine post, one crept in! This year's addition to my series on research about peer review in science journals: 5 Things We Learned About Peer Review in 2020.




It was a monster month in Covid-19 and vaccines – and my monthly vaccines roundup was a monster, too:

Variants, 3 New Covid Vaccines, and Contested Efficacy Claims: A Month of Seismic Shifts and Confusion.

And a debunking post: Unpacking Doshi's Take at BMJ on Covid Vaccine Trials.

Early in the month I talked about Covid vaccines with Alexander Heffner for an NPR podcast. And late in the month I was on BBC Newsnight, answering questions about the Oxford/AstraZeneca vaccine again.





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